Fractional strong matching preclusion for two variants of hypercubes

Let F be a subset of edges and vertices of a graph G. If G-F has no fractional perfect matching, then F is a fractional strong matching preclusion set of G. The fractional strong matching preclusion number is the cardinality of a minimum fractional strong matching preclusion set. In this paper, we mainly study the fractional strong matching preclusion problem for two variants of hypercubes, the multiply twisted cube and the locally twisted cube, which are two of the most popular interconnection networks. In addition, we classify all the optimal fractional strong matching preclusion set of each

Fractional matching preclusion for butterfly derived networks

The matching preclusion number of a graph is the minimum number of edges whose deletion results in a graph that has neither perfect matchings nor almost perfect matchings. As a generalization, Liu and Liu [18] recently introduced the concept of fractional matching preclusion number. The fractional matching preclusion number (FMP number) of G, denoted by fmp(G), is the minimum number of edges whose deletion leaves the resulting graph without a fractional perfect matching. The fractional strong matching preclusion number (FSMP number) of G, denoted by fsmp(G), is the minimum number of vertices and edges whose deletion leaves the resulting graph without a fractional perfect matching. In this paper, we study the fractional matching preclusion number and the fractional strong matching preclusion number for butterfly network, augmented butterfly network and enhanced butterfly network

Interpersonal Behaviours Questionnaire-self（IBQs-J）の日本語版の開発および妥当性の検討

The objectives of the present study are to develop a Japanese version of the Interpersonal Behaviours Questionnaire-self (IBQs) and to validate it. The IBQs is a scale for assessing individual self-reports of interpersonal behaviours towards others based on Self-Determination Theory within the context of need-supportive and need-thwarting behaviours. The respondents were asked to selfreport concerning their interpersonal behaviours towards people within their lives. Consistent with prior research, the results of confirmatory factor analyses revealed that a six-factor structure has the best model fit. Based on that analysis, we excluded item-9 from the subsequent analysis because of its low factor loading. These results support the validity of the scale and correlation analyses suggest that the subscales for need-supportive behaviours are positively correlated with basic need satisfaction and well-being, while the subscales for need-thwarting behaviours are positively correlated with basic need frustration and ill-being. We conclude that the IBQs-J is a valid scale for investigating self-reports concerning need-supportive and need-thwarting behaviours towards others

3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases

BACKGROUND: Metastasis is a major cause of morbidity and mortality in breast cancer with tumor cell invasion playing a crucial role in the metastatic process. PDK1 is a key molecule that couples PI3K to cell proliferation and survival signals in response to growth factor receptor activation, and is oncogenic when expressed in mouse mammary epithelial cells. We now present evidence showing that PDK1-expressing cells exhibit enhanced anchorage-dependent and -independent cell growth and are highly invasive when grown on Matrigel. These properties correlate with induction of MMP-2 activity, increased MT1-MMP expression and a unique gene expression profile. METHODS: Invasion assays in Matrigel, MMP-2 zymogram analysis, gene microarray analysis and mammary isografts were used to characterize the invasive and proliferative function of cells expressing PDK1. Tissue microarray analysis of human breast cancers was used to measure PDK1 expression in invasive tumors by IHC. RESULTS: Enhanced invasion on Matrigel in PDK1-expressing cells was accompanied by increased MMP-2 activity resulting from stabilization against proteasomal degradation. Increased MMP-2 activity was accompanied by elevated levels of MT1-MMP, which is involved in generating active MMP-2. Gene microarray analysis identified increased expression of the ECM-associated genes decorin and type I procollagen, whose gene products are substrates of MT1-MMP. Mammary fat pad isografts of PDK1-expressing cells produced invasive adenocarcinomas. Tissue microarray analysis of human invasive breast cancer indicated that PDK1pSer241 was strongly expressed in 90% of samples. CONCLUSION: These results indicate that PDK1 serves as an important effector of mammary epithelial cell growth and invasion in the transformed phenotype. PDK1 mediates its effect in part by MT1-MMP induction, which in turn activates MMP-2 and modulates the ECM proteins decorin and collagen. The presence of increased PDK1 expression in the majority of invasive breast cancers suggests its importance in the metastatic process

Robust Multimodal Failure Detection for Microservice Systems

Proactive failure detection of instances is vitally essential to microservice systems because an instance failure can propagate to the whole system and degrade the system's performance. Over the years, many single-modal (i.e., metrics, logs, or traces) data-based nomaly detection methods have been proposed. However, they tend to miss a large number of failures and generate numerous false alarms because they ignore the correlation of multimodal data. In this work, we propose AnoFusion, an unsupervised failure detection approach, to proactively detect instance failures through multimodal data for microservice systems. It applies a Graph Transformer Network (GTN) to learn the correlation of the heterogeneous multimodal data and integrates a Graph Attention Network (GAT) with Gated Recurrent Unit (GRU) to address the challenges introduced by dynamically changing multimodal data. We evaluate the performance of AnoFusion through two datasets, demonstrating that it achieves the F1-score of 0.857 and 0.922, respectively, outperforming the state-of-the-art failure detection approaches

PPARδ Activation Acts Cooperatively with 3-Phosphoinositide-Dependent Protein Kinase-1 to Enhance Mammary Tumorigenesis

Peroxisome proliferator-activated receptorδ (PPARδ) is a transcription factor that is associated with metabolic gene regulation and inflammation. It has been implicated in tumor promotion and in the regulation of 3-phosphoinositide-dependent kinase-1 (PDK1). PDK1 is a key regulator of the AGC protein kinase family, which includes the proto-oncogene AKT/PKB implicated in several malignancies, including breast cancer. To assess the role of PDK1 in mammary tumorigenesis and its interaction with PPARδ, transgenic mice were generated in which PDK1 was expressed in mammary epithelium under the control of the MMTV enhancer/promoter region. Transgene expression increased pT308AKT and pS9GSK3β, but did not alter phosphorylation of mTOR, 4EBP1, ribosomal protein S6 and PKCα. The transgenic mammary gland also expressed higher levels of PPARδ and a gene expression profile resembling wild-type mice maintained on a diet containing the PPARδ agonist, GW501516. Both wild-type and transgenic mice treated with GW501516 exhibited accelerated rates of tumor formation that were more pronounced in transgenic animals. GW501516 treatment was accompanied by a distinct metabolic gene expression and metabolomic signature that was not present in untreated animals. GW501516-treated transgenic mice expressed higher levels of fatty acid and phospholipid metabolites than treated wild-type mice, suggesting the involvement of PDK1 in enhancing PPARδ-driven energy metabolism. These results reveal that PPARδ activation elicits a distinct metabolic and metabolomic profile in tumors that is in part related to PDK1 and AKT signaling

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Sociodemographic and Health Profiles of the Oldest Old In China

Unique data from a 1998 healthy longevity baseline survey provide demographic, socio-economic, and health characteristics of the oldest old, aged 80-105, in China. This subpopu-lation is growing rapidly and is likely to need extensive social and health services. A large majority of Chinese oldest old live with their children and rely mainly on children for financial support and care. Most Chinese oldest old had no or very little education. Ability to function independently in daily living declines rapidly and self-rated health declines moderately across the oldest old ages. As compared to their urban counterparts, the rural oldest old have far less pension support, are significantly less educated, and are more likely to be widowed and to rely on children for support. Apart from higher rates of survival, the female oldest old in China are far more disadvantaged than the male oldest old. Copyright 2002 by The Population Council, Inc..

L'enquête sur la longévité en bonne santé. L'espérance de vie sans incapacité des personnes très âgées en Chine

Zeno Yi. Val pel James W . Xiao Zhenyu. Zhang Chunyuan, Liu Yuzhi - L'enquête sur la longévité en bonne santé : l'espérance de vie sans incapacité des personnes très âgées en Chine Cet article décrit succinctement le contexte, les objectifs, le plan d'étude et l'évaluation de la qualité des données de l'enquête chinoise de 1998 sur la longévité en bonne santé II présente aussi les premiers résultats concernant le thème specitique de l'espérance de vie sans incapacité comparée à l'espérance de vie avec incapacité Diverses mesures attestent la qualité généralement bonne des declarations d'âge et d'autres aspects qualitatifs des données de notre enquête de 1998 Les données relatives aux activités de la vie quotidienne collectées auprès de 2 274 centenaires, 3 035 nonagénaires et 3 496 octogénaires montrent que les personnes très âgées ont plus de chance de poursuivre les activités de la vie quotidienne jusqu'à leurs derniers jours si elles vivent en milieu rural plutôt qu'en ville Le pourcentage des hommes très âges qui restent actits est supérieur à celui des femmes, bien que celles-ci aient une longévité totale supérieure Nous terminons par quelques explications de ces differences intéressantes selon le sexe et l'habitat rural ou urbainZeng Yi, Vaupel James W , Xiao Zhenyu, Zhang Chunyuan, Liu Yuzhi - Encuesta sobre la longevidad en buena salud: la esperanza de vida sin incapacidades en edades muy avanzadas en China Este articulo háce una descnpción sucinta del contexto, objetivos, plan de estudio y evaluacion de la cahdad de los datos de la encuesta china de 1998 sobre la longevidad en buena salud Tambien présenta los pnmeros resultados de la investigacion sobre la esperanza de vida sin incapacidad comparada con la esperanza de vida con incapacidad Vanos indicadores sugieren que la cahdad de los datos relativos a las declaraciones de edad y otros aspectos cua- htativos es generalmente buena Los datos relativos a las actividades cotidianas, disponibles para 2 274 centenanos, 3 035 nonagenanos y 3 496 octogenanos, muestran que entre las per- sonas mayores existe mayor probabilidad de seguir reahzando las actividades de la vida coti- diana si viven en un medio rural El porcentaje de personas mayores que permanecen activos es superior entre los hombres que entre las mujeres. aunque para estas la longevidad total sea mas elevada El articulo présenta algunas explicaciones de estas interesantes diterencias por sexo y segun el lugar de residencia (rural, urbano)Yi Zeng, Vaupel James W., Zhenyu Xiao, Chunyuan Zhang, Yuzhi Liu. L'enquête sur la longévité en bonne santé. L'espérance de vie sans incapacité des personnes très âgées en Chine. In: Population, 56ᵉ année, n°1-2, 2001. Perspectives biodémographiques de la longévité humaine, sous la direction de Jean-Marie Robine. pp. 109-131